A multicomponent access to 1,3-thiazine-6-phenylimino-5-carboxylates
نویسندگان
چکیده
منابع مشابه
Multicomponent synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thiones.
Non-fused 3,6-dihydro-2H-1,3-thiazine-2-thiones constitute a so far rather unexplored class of compounds, with the latest report dating back more than two decades. Thiazine-2-thiones contain an endocyclic dithiocarbamate group, which is often found in pesticides, in substrates for radical chemistry and in synthetic intermediates towards thioureas and amidines. We now report the multicomponent r...
متن کاملMulticomponent domino reactions of hydrazinecarbodithioates: concise access to 3-substituted 5-thiol-1,3,4-thiadiazolines.
Two classes of addition/cycloaddition cascade reactions of hydrazinecarbodithioate (1) have been developed under mild reaction conditions. Reaction of hydrazinecarbodithioate (1) with formaldehyde solution (2) and propiolic acid (3) gives 3-propargyl-5-thiol-2,3-dihydro-1,3,4-thiadiazoles (5) via a decarboxylative coupling/cycloaddition domino sequence. When propiolic acid (3) is switched to ph...
متن کاملA three-component reaction for rapid access to underexplored 1,3-thiazine-2-thiones.
Driven by the shortage of known effective possibilities for the synthesis of 4-hydroxy-3,4-dihydro-2H-1,3-thiazine-2-thiones on the one hand and the promising potential of these structures as novel drug candidates on the other hand, synthetic access to 4-hydroxy-3,4-dihydro-2H-1,3-thiazine-2-thiones was developed. The desired products could be synthesized effectively and facilely starting from ...
متن کاملBIBD ’ s for ( 13 , 5 , 5 ) , ( 16 , 6 , 5 ) and ( 21 , 6 , 4 ) Possessing Possibly an Automorphism of Order 3
When trying to enumerate all BIBD’s for given parameters, their natural solution space appears to be huge and grows extremely with the number of points of the design. Therefore, constructive enumerations are often carried out by assuming additional constraints on design’s structure, automorphisms being mostly used ones. It remains a hard task to construct designs with trivial automorphism group...
متن کاملSynthesis of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using nanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst
Nanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst have been used for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates by the four component reaction of dimethylacetylenedicarboxylate, hydrazinehydrate, malononitrile and aromatic aldehydes in water at room temperature. In this research Nano-ZnZr4(PO4)6 coordinate with the active groups(...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2016
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2016.06.007